2021 USCAP Maude Abbott Lecture - Neuroendocrine Carcinomas of the Head and Neck:
Ikusasa Elidlule, Lamanje kanye nelingenzeka

U-BRUCE M. WENIG, MD

USihlalo kanye neLungu Eliphezulu
UMnyango Wezokugula
Isikhungo Somdlavuza saseMoffitt
UProfesa Wesayensi Ye-Oncological
I-University of South Florida
ETampa, eFlorida

Isikhathi sokusebenza: Ihora eli-1 nemizuzu engama-26

OKUQUKETHWE UHLELO

I-Neuroendocrine neoplasms (NEN) ivela cishe kuzo zonke izitho. Ukuthuthukiswa kwe-embryologic ye-NEN kube yindaba yempikiswano ukuthi ikhona noma ayikho imvelaphi evamile ye-neural crest. Ngaphansi kwesisekelo somsuka ovamile we-neural crest, ukuba khona kwendlela evamile ye-biochemical kumaseli e-neuroendocrine ahlanganisa ukumuncwa kanye ne-decarboxylation yama-amine precursors kwahlelwa ukuvumela ukuthi lawa maseli ahlonzwe njenge-histochemically futhi okuholele ekusetshenzisweni kwesifinyezo se-APUD (Amine Precursor. I-Uptake ne-Decarboxylation) ukuchaza amaseli akule sistimu. Ucwaningo olwalandela lwasusa imvelaphi evamile ye-neural crest kanye nokuhlukaniswa kwe-Dispersed Neuroendocrine Cell System yamukelwa i-NEN. Ukuhlukaniswa kwe-NEN kube nenguquko lapho izinhlelo zamanje kungakhathalekile ukuthi zisuka kuphi ziye zaphakamisa ukuthi kusetshenziswe i-nomenclature esungulelwe i-NEN yamathumbu kanye ne-pancreatic. Ngaphandle komgudu wamathumbu, amanyikwe namaphaphu, isifunda sekhanda nentamo siphakathi kwezindawo ezivame ukwenzeka ze-NEN futhi kulesi sifunda i-neuroendocrine carcinoma iwuhlobo oluvame kakhulu lwe-NEN ethile. Le nkulumo izogxila kuma-neuroendocrine carcinomas ekhanda nasentanyeni ebuyekeza izici zabo ze-clinicopathologic futhi idingida ukufakwa kwawo ngaphakathi kohlaka lokuhlukanisa okufanayo oluhlongozwayo kwenye i-NEN ethile yesayithi.

IZINJONGO ZOKUFUNDA

1. Xoxa ngokukhula kwe-embryologic ye-neoplasms ye-neuroendocrine
2. Chaza indlela yokuxilonga yekhanda nentamo neuroendocrine neoplasms eqhathanisa lezi zindlela nalezo zezinye isayithi le-NEN ethile.
3. Nquma ukuthi uhlaka oluhlongozwayo lokuhlukanisa oluvamile lwe-NEN luyasebenza yini ku-NEN yekhanda nentamo